Written Question · S2W-25354 · Session 2
Further to the answer to question S2W-24315 by Mr Andy Kerr on 22 March 2006 in which it states that, “Since that time there have been a se…
The question
To ask the Scottish Executive, further to the answer to question S2W-24315 by Mr Andy Kerr on 22 March 2006 in which it states that, “Since that time there have been a series of studies which have reinforced the evidence that MMR is safe”,whether it will list the studies referred to in chronological order, identifying those studies which involved the clinical examination of autistic children.
The answer
The key research papers listedsupport the view that there is no link between MMR and autism:
GillbergC & Heijbel H, (1998). MMR and autism [commentary]. Autism, The InternationalJournal of Research and Practice; 2:423-424. http://www.sagepub.co.uk
TaylorB et al (1999) Autism andmeasles, mumps and rubella vaccine: no epidemiological evidence for a causal association.The Lancet; 353:2026-29. http://www.thelancet.com
KayeJ et al (2001). Mumps, measlesand rubella vaccine and the incidence of autism recorded by general practitioners:A time trend analysis. British Medical Journal 322:460-3.
http://bmj.bmjjournals.com
FarringtonP et al (2001). MMR and autism:Further evidence against a causal association Vaccine 19:3632-5 Volume 19,Issue 27, 14 June 2001, pages 3632-3635. http://www.elsevier.com
Fombonne E, Chakrabarti S. Noevidence for a new variant of measles-mumps-rubella-induced autism. Pediatrics 2001;108(4):E58.
Ceyhan M, Kanra G, Erdem G, KanraB. Immunogenicity and efficacy of one dose measles-mumps-rubella (MMR) vaccine attwelve months of age as compared to monovalent measles vaccination at nine monthsfollowed by MMR revaccination at fifteen months of age. Vaccine 2001;19(31):4473-8.
Davis RL, Kramarz P, Bohlke K,Benson P, Thompson RS, Mullooly J, et al. Measles-mumps-rubella and other measles-containingvaccines do not increase the risk for inammatory bowel disease: a case-control studyfrom the Vaccine Safety Datalink project. Archives of Pediatric and Adolescent Medicine2001;155(3):354-9.
BlackC (2002) Relation of childhood gastrointestinaldisorders to autism: nested case-control study using data from the UK General PracticeResearch Database. British Medical Journal 325:419-21.
http://bmj.bmjjournals.com.
TaylorB et al (2002) Measles, mumpsand rubella vaccination and bowel problems or development regression in childrenwith autism: population study. British Medical Journal 324: 393-396.
http://bmj.bmjjournals.com.
DonaldA & Muthu V (2002) No evidencethat MMR vaccine is associated with autism or bowel disease. Clinical Evidence,7:331-40.http://www.clinicalevidence.com.
MadsenKM et al (2002). A population-basedstudy of measles, mumps and rubella vaccination and autism. New England Journal of Medicine 347: 1477-82. http://content.nejm.org
da Cunha SS, Rodrigues LC, BarretoML, Dourado I. Outbreak of aseptic meningitis and mumps after mass vaccination withMMR vaccine using the Leningrad-Zagreb mumps strain. Vaccine 2002;20 (7-8):1106{12.
DeStefano F, Gu D, Kramarz P,Truman BI, Iademarco MF, Mullooly JP, Jackson LA, et al. Childhood vaccinationsand risk of asthma. Pediatric Infectious Disease Journal 2002;21(6):498-504.
Makela A, Nuorti JP, PeltolaH. Neurologic disorders after measlesmumps-rubella vaccination. Pediatrics 2002;110(5):957-63.
SzatmariP. et al. ( 2003 ). The causeof autism spectrum disorders. British Medical Journal 326: 173-4. http://bmj.bmjjournals.com
WilsonK et al. (2003). Associationof Autistic Spectrum Disorder and the Measles, Mumps and Rubella Vaccine. ArchPediatr Adolesc Med
GillbergC & Heijbel H, (1998). MMR and autism [commentary]. Autism, The InternationalJournal of Research and Practice; 2:423-424. http://www.sagepub.co.uk
TaylorB et al (1999) Autism andmeasles, mumps and rubella vaccine: no epidemiological evidence for a causal association.The Lancet; 353:2026-29. http://www.thelancet.com
KayeJ et al (2001). Mumps, measlesand rubella vaccine and the incidence of autism recorded by general practitioners:A time trend analysis. British Medical Journal 322:460-3.
http://bmj.bmjjournals.com
FarringtonP et al (2001). MMR and autism:Further evidence against a causal association Vaccine 19:3632-5 Volume 19,Issue 27, 14 June 2001, pages 3632-3635. http://www.elsevier.com
Fombonne E, Chakrabarti S. Noevidence for a new variant of measles-mumps-rubella-induced autism. Pediatrics 2001;108(4):E58.
Ceyhan M, Kanra G, Erdem G, KanraB. Immunogenicity and efficacy of one dose measles-mumps-rubella (MMR) vaccine attwelve months of age as compared to monovalent measles vaccination at nine monthsfollowed by MMR revaccination at fifteen months of age. Vaccine 2001;19(31):4473-8.
Davis RL, Kramarz P, Bohlke K,Benson P, Thompson RS, Mullooly J, et al. Measles-mumps-rubella and other measles-containingvaccines do not increase the risk for inammatory bowel disease: a case-control studyfrom the Vaccine Safety Datalink project. Archives of Pediatric and Adolescent Medicine2001;155(3):354-9.
BlackC (2002) Relation of childhood gastrointestinaldisorders to autism: nested case-control study using data from the UK General PracticeResearch Database. British Medical Journal 325:419-21.
http://bmj.bmjjournals.com.
TaylorB et al (2002) Measles, mumpsand rubella vaccination and bowel problems or development regression in childrenwith autism: population study. British Medical Journal 324: 393-396.
http://bmj.bmjjournals.com.
DonaldA & Muthu V (2002) No evidencethat MMR vaccine is associated with autism or bowel disease. Clinical Evidence,7:331-40.http://www.clinicalevidence.com.
MadsenKM et al (2002). A population-basedstudy of measles, mumps and rubella vaccination and autism. New England Journal of Medicine 347: 1477-82. http://content.nejm.org
da Cunha SS, Rodrigues LC, BarretoML, Dourado I. Outbreak of aseptic meningitis and mumps after mass vaccination withMMR vaccine using the Leningrad-Zagreb mumps strain. Vaccine 2002;20 (7-8):1106{12.
DeStefano F, Gu D, Kramarz P,Truman BI, Iademarco MF, Mullooly JP, Jackson LA, et al. Childhood vaccinationsand risk of asthma. Pediatric Infectious Disease Journal 2002;21(6):498-504.
Makela A, Nuorti JP, PeltolaH. Neurologic disorders after measlesmumps-rubella vaccination. Pediatrics 2002;110(5):957-63.
SzatmariP. et al. ( 2003 ). The causeof autism spectrum disorders. British Medical Journal 326: 173-4. http://bmj.bmjjournals.com
WilsonK et al. (2003). Associationof Autistic Spectrum Disorder and the Measles, Mumps and Rubella Vaccine. ArchPediatr Adolesc Med
In the Official Report
No contribution in the Official Report cites S2W-25354 by reference.